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Watch Closely (1)pentobarbital will minimize the extent or effect of fentanyl transdermal by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Keep track of Carefully. Coadministration of fentanyl with CYP3A4 inducers could lead on to the minimize in fentanyl plasma concentrations, insufficient efficacy or, possibly, enhanceme